IndraLab

Statements

BECN1 activates mutated ATXN3. 3 / 3
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"As a corollary, overexpression of beclin 1 can stimulate the autophagic flux and promote clearance of the mutant ataxin-3 in brains of SCA3 mouse models."
33483467
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"In neuroblastoma and rat models of SCA3, lentiviral overexpression of Beclin-1 increased autophagic flux, increased the clearance of mutant Ataxin-3, and appeared to reduce neuronal pathology in the s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31887286
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"Additional evidence supporting autophagy induction as a viable therapeutic target is the fact that lentiviral mediated overexpression of the autophagy protein beclin-1 increases clearance of mutant ATXN3 and decreases aggregates in a MJD rat model."
22133674