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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

BECN1 activates mutated ATXN3. 2 / 2

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"Additional evidence supporting autophagy induction as a viable therapeutic target is the fact that lentiviral mediated overexpression of the autophagy protein beclin-1 increases clearance of mutant ATXN3 and decreases aggregates in a MJD rat model."

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"As a corollary, overexpression of beclin 1 can stimulate the autophagic flux and promote clearance of the mutant ataxin-3 in brains of SCA3 mouse models."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...