IndraLab

Statements

BECN1 activates mutated ATXN3. 2 / 2
| 2
reach
"Additional evidence supporting autophagy induction as a viable therapeutic target is the fact that lentiviral mediated overexpression of the autophagy protein beclin-1 increases clearance of mutant ATXN3 and decreases aggregates in a MJD rat model."
22133674
reach
"As a corollary, overexpression of beclin 1 can stimulate the autophagic flux and promote clearance of the mutant ataxin-3 in brains of SCA3 mouse models."
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