IndraLab

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Pregnenolone inhibits TRAF6. 2 / 2

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"Interestingly, pregnenolone did not inhibit TRAF6 or CRF, suggesting that structural requirements for inhibition of TLR signaling are cell type specific, and likely related to the requirements of the binding partners - both TLR4 and GABA A R alpha2 subunits."

30718548

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reach

"While pregnenolone lacks GABAergic activity, and failed to block TRAF6 or CRF, it is possible that it may interfere with TLR4 and MyD88 binding and/or the PKA - pCREB pathway in the VTA."

30718548

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IndraLab

Statements

Pregnenolone inhibits TRAF6. 2 / 2

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