IndraLab

Statements

USP7 inhibits NEK2. 3 / 3
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"Together, our data therefore indicate that I3MO downregulates the level of USP7 and promotes NEK2 degradation, resulting in the suppression of downstream targets and NF-κB signaling, and inducing cell death in bortezomib resistant MM cells."
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"Furthermore, overexpression of USP7 reduced the half-life of NEK2, supporting the concept that USP7 enhances NEK2 stability."
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"Franqui-Machin et al. showed that USP7 could prevent NEK2 from undergoing ubiquitination-dependent degradation and stabilize it."
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