IndraLab

Statements

HCN4 activates PITX2. 2 / 2
| 2
reach
"Blocking of HCN4 channels (both pharmacologically and physiologically) induces a significant decrease in Pitx2 signal in its anterior-posterior spread and area of the signal."
28818840
reach
"Both overexpressing HCN4 and injection of dominant negative HCN4 mRNA disrupt the localization of key morphogenetic patterning genes, Xnr-1, Lefty, Pitx2, and BMP-4, resulting in hearts with incorrect positional orientation and morphology."
28702127