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"Further investigation also showed the endogenous BRD4 binding with UCHL3 which was enhanced by rIL6 but inhibited by pacritinib (Figs."

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"Of note, our experiments were performed in the presence of IL6/8. whether other deubiquitinases are preferential in other contexts need to be further investigated.To investigate if UCHL3 binds to BRD4, we performed reciprocal co-immunoprecipitation assays in cells transfected with BRD4, alone or with UCHL3 and JAK2-V617F."

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