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USP19 increases the amount of ME1. 2 / 2
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"We found that USP19 inhibition significantly decreased ME1 protein levels in CRC cells ( Figures 1 C and S1 E) and that they could be rescued by wild-type (WT) USP19 but not by a ubiquitination-defect[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand, USP19 inhibition severely retarded CRC cell growth in MTT assay and reduced the expression of ME1, while these defects were successfully rescued after ME1 overexpression ( Figures S[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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