IndraLab

Statements

USP9X deubiquitinates NFE2L2. 9 / 9
| 9
reach
"Further researches revealed that USP9X could reduce the Nrf2 ubiquitination level in AGEs-treated GMCs, suggesting that USP9X, depending on its deubiquitinase activity, stabilized Nrf2 protein, and in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32442538
reach
"These data suggested that USP9X, relying on its deubiquitinase activity, reduced Nrf2 ubiquitination level to increase its protein expression, promoting the activation of Nrf2-ARE pathway.DN is one of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32442538
reach
"Considering that USP9X increased the protein expression of Nrf2 in model cells in a deubiquitinase activity-dependent manner, we supposed that USP9X might directly deubiquitinate Nrf2 to inhibit its d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32442538
reach
"USP9X suppresses ferroptosis in diabetic kidney disease by deubiquitinating Nrf2 in vitro."
39967230
reach
"An interaction between USP9X and Nrf2 has been verified and USP9X deubiquitinated Nrf2."
39967230
reach
"USP9X deubiquitinated Nrf2 in HK-2 cells."
39967230
reach
"Furthermore, USP9X overexpression reduced polyubiquitination of Nrf2, revealing that USP9X deubiquitinated Nrf2 in HK-2 cells (Figure 2(K))."
39967230
reach
"Based on that Nrf2 ubiquitination is closely related to DN, and that USP9X can disrupt the ubiquitination and degradation process of substrate proteins which exert anti-OSS effects, we speculated that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32442538
reach
"However, USP9X overexpression after Nrf2 interference could not reverse the above changes induced by AGEs ( Fig. 6 ), suggesting that Nrf2 mediated the inhibitory effects of USP9X on fibrosis developm[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32442538