IndraLab

Statements

IRS1 phosphorylated on S1101 is inactive. 3 / 3
3 |
signor
"Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)."
15364919
signor
"Tyrosine phosphorylation of IRS-1 initiates insulin signaling, whereas serine/threonine phosphorylation alters the ability of IRS-1 to transduce the insulin signalInsulin increased the phosphorylation of Ser312, Ser616, Ser636, Ser892, Ser1101, and Ser1223"
17360977
signor
"Nevertheless, s6k1-deficient mice remain sensitive to insulin owing to the apparent loss of a negative feedback loop from s6k1 to insulin receptor substrate 1 (irs1), which blunts s307 and s636/s639 phosphorylation; thus under conditions of nutrient satiation s6k1 negatively regulates insulin."
15306821