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OTUB1 deubiquitinates CD274. 4 / 4
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"Mechanistically, we demonstrate that <span class="match term0">OTUB1</span> interacts with and removes K48-linked ubiquitin chains from the <span class="match term1">PD-L1</span> intracellular domain in a manner dependent on its deubiquitinase activity to hinder the degradation of <span class="match term1">PD-L1</span> through the ERAD pathway"
33328570
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"The immunosuppressive effect of PKP3 depends on the deubiquitination of PD-L1 mediated by OTUB1 (a deubiquitinase), which protects PD-L1 from degradation."
37264402
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"Deubiquitination of PD-L1 by OTUB1 promotes the degradation of PD-L1 through the endoplasmic reticulum-associated degradation (ERAD) pathway, facilitating CD8 T lymphocyte infiltration and increasing cytotoxicity ability [9]."
37340461
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"Contrary, it is reported that PD-L1 can be deubiquitinated by CSN5, USP22, USP7, USP9X, and OTUB1 (Feng et al.)."
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