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USP22 activates Cell Survival. 4 / 4
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"Therefore, up-regulation of USP22 expression will lead to abnormal activation of multiple pathways to promote cell survival while down-regulation of USP22 expression can induce cell cycle arrest at G0/G1 phase in different types of cancer cells (Zhang et al., 2008)."
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"Similarly , Zhao et al. reported that USP22 depletion suppressed cell survival and proliferation as well as tumor growth and lung metastasis of anaplastic thyroid carcinoma cells25 ."
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"USP22 was highly expressed in NPC cells and promoted cell viability and proliferation."
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"Silencing of either USP22 or RNF40 reduced short-term cell viability and clonogenic growth of osteosarcoma cells (Fig. 6A and B)."
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