IndraLab

Statements

CACNA1B binds FMR1. 2 / 2
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"Interestingly, we find here that the effect of FMRP on Ca V 2.2 expression is antagonized by a proteasome inhibitor, and we found that the interaction between FMRP and Cav2.2 does not co-immunoprecipitate Ca V β subunits, suggesting that it occurs with channels that have lost, or subsequently lose, the protective interaction with Ca V β subunits xref ."
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"For instance, knockdown experiments have suggested that FMRP may interact with N-type calcium channel Cav2.2 [ xref ] and repress NMDAR subunit translation [ xref ]."
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