IndraLab

Statements

FMR1 binds CACNA1B. 3 / 3
| 3
sparser
"Among the three Cav2 isoforms, FMRP interacts with the c-terminal domain of CaV2.2 ( xref , xref )."
36809742
sparser
"Interestingly, we find here that the effect of FMRP on Ca V 2.2 expression is antagonized by a proteasome inhibitor, and we found that the interaction between FMRP and Cav2.2 does not co-immunoprecipitate Ca V β subunits, suggesting that it occurs with channels that have lost, or subsequently lose, the protective interaction with Ca V β subunits xref ."
24709664
sparser
"For instance, knockdown experiments have suggested that FMRP may interact with N-type calcium channel Cav2.2 [ xref ] and repress NMDAR subunit translation [ xref ]."
26493318