IndraLab

Statements

Lidocaine inhibits SCN5A. 9 / 17
1 1 6 | 1 7 1
reach
"Additionally, lidocaine can inactivate the Nav1.5 α subunit present in cardiomyocytes ( Elajnaf, Baptista-Hon, & Hales, 2018 )."
38701900
reach
"Lidocaine, a topical therapeutic agent for neuropathic pain, inhibited Nav1.7 and Nav1.5 with similar potency (IC 50 values: 912.9 and 2380.4 μM, respectively) in the same automated patch-clamp assays[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38776832
eidos
"Further investigations indicated that blocking NaV1.5 by lidocaine or sodium ion channel blocker decreased the ovarian malignancy through inactivation of FAK / Paxillin signaling pathway ( Figure 7 ) ."
33280262
reach
"As previously reported, lidocaine inhibits ovarian cancer cell growth, migration, and invasion by blocking Nav1.5 and its downstream pathway (Liu et al., 2021)."
40309242
reach
"Moreover, ropivacaine, lidocaine, TTX, and a siRNA specifically targeting Nav1.5 could inhibit Nav1.5 channel function and invasion of metastatic colon cancer SW620 cells, and the Nav1.5 channel activator veratridine promoted SW620 cell invasion (9,18)."
35116732
sparser
"Additionally, lidocaine can inactivate the Nav1.5 α subunit present in cardiomyocytes ( Elajnaf, Baptista-Hon, & Hales, 2018 )."
38701900
reach
"The concentration dependence of the lidocaine block of hH1 Na current was consistent with a binding stoichiometry of 1:1."
1336062
reach
"Fast-onset lidocaine block of rat NaV1.4 channels suggests involvement of a second high-affinity open state."
26922882
reach
"In contrast, lidocaine markedly reduced hH1 I Na after a prepulse to -100 mV."
10620286