IndraLab

Statements

USP18 activates Infections. 3 / 3
| 3
reach
"Knockout of USP18 abrogated significantly the infection of HIV-1 by more than 6-folds, which correlated strongly with reduced phosphorylated SAMHD1.USP18 blocked the interferon-induced signalling in the THP-1 cells measured by ISG induction by real time PCR."
| PMC
reach
"We speculate that by blocking IFN-α signaling, USP18 expression may lead to an enhanced susceptibility to infection with interferon-sensitive viruses and enhanced viral proliferation."
27009955
reach
"We found that USP18 increased HIV-1 infection by more than 40-fold and HIV-2Δvpx by over 7-fold."
| PMC