IndraLab

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SOX18 binds OTUB1. 6 / 6
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"Mechanistically, our data proved that SOX18 directly bound to the OTUB1 promoter region and activated its transcription."
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"Dual-luciferase reporter assay, chromatin-immunoprecipitation (ch-IP) and DNA pull-down were employed to verify SOX18 binding to the OTUB1 (OTU domain-containing ubiquitin aldehyde binding protein 1) promoter."
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"The binding of SOX18 to the OTUB1 promoter was also verified by Ch-IP assay (Fig.  xref E)."
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"In addition, as demonstrated by DNA pull-down, SOX18 wild-type bound to the promoter of OTUB1, but the SOX18 mutant did not bind to OTUB1 (Fig.  xref F)."
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"Our series of experiments verified that SOX18 bound to the OTUB1 promoter region and promoted its transcription."
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"Totally, our data confirmed that SOX18 bound to the OTUB1 promoter and transcriptionally upregulated OTUB1."
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