IndraLab

Statements

USP4 increases the amount of TP53. 2 / 2
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"More importantly, in response to cisplatin treatment, USP4 deficiency resulted in up-regulation of p53 expression both at transcriptional level and translational level."
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"Previous studies have found that USP4 can inhibit p53 transcription and pro-apoptotic functions by stabilizing HDAC2 [17], whereas the deubiquitinase USP4 stabilizes Twist1 protein to promote lung cancer stemness [18]."
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