IndraLab

Statements

UCHL1 increases the amount of CDKN1B. 5 / 5
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"On one hand, UCH-L1 promotes the cytoplasmic p27 level by transferring p27 from the nucleus to the cytoplasm; on the other hand, UCH-L1 reduces the degradation of p27 by enhancing the de-ubiquitinatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, these data demonstrate that UCH-L1 inhibition specifically reduced cytoplasmic p27 Kip1 protein content in PHN.As in human and rodent MGN, over-expression of UCH-L1 in cultured podocyt[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, chemical inhibition of UCH-L1 hydrolase activity ( Fig. 6 C, (3); D (3)) in UCH-L1 over-expressing podocytes significantly decreased cytoplasmic p27 Kip1 levels but did not significantl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Especially cytoplasmic levels of p27 Kip1 were modulated by podocyte UCH-L1 content and enzymatic activity."
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"Furthermore, inhibition of UCH-L1 hydrolase activity resulted in normalized levels of poly-ubiquitinated p27 Kip1 and reduced cytoplasmic p27 Kip1 levels indicating re-established proteasomal degradat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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