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Carbon monoxide inhibits EIF2AK1. 3 / 3

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"Other investigators reported that CO directly inhibited the kinase activity of HRI in vitro [51,52]."

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"HRI is activated by NO binding to the heme, which displaces both endogenous ligands, but HRI is inhibited by formation of the 6-coordinate CO adduct."

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"Consistent with this hypothesis, the ability of CO to suppress the activity of HRI [14] correlates with its ability to stabilize the interaction between the two domains ( Fig. 2 )."

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Carbon monoxide inhibits EIF2AK1. 3 / 3

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