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PKA activates SCN5A. 11 / 11
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"Several studies have reported that cAMP and PKA directly modulate NaV1.5 and thereby I Na density [XREF_BIBR - XREF_BIBR]."
31077706
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"Furthermore, it was shown that a cocktail of inflammatory mediators containing bradykinin, PGE-2, histamine, 5-HT, and adenosine 5′-triphosphate altered the gating properties of Nav1.5 and both protein kinase A and protein kinase C mediated the inflammatory mediators induced alteration in the gating properties of Nav1.5 [24]."
35448095
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"Early findings that cardiac Na + current is increased by beta-endorphin XREF_BIBR and a G-protein and PKA pathway XREF_BIBR were followed by the discovery that PKA upregulates trafficking of NaV1.5 into the plasma membrane XREF_BIBR, XREF_BIBR."
19787026
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"These were used to localize the structural determinant in the hH1 sequence responsible for PKA modulation of hH1."
9032680
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"Persistent PKA activation promotes Nav1.5 trafficking to the cytoplasmic membrane, especially at intercalated discs [47]."
40334239
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"Although we did not show this directly, several studies have reported that both cAMP and PKA directly modulate NaV1.5 and I Na density [XREF_BIBR - XREF_BIBR]."
31077706
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"Thus I KATP together with I Ks may be involved in action potential shortening during exercise.There is some consensus that β-adrenergic stimulation and PKA activation increases the cardiac SCN5A sodiu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28223225
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"Several studies have reported that cAMP and PKA directly modulate NaV1.5 and thereby INa density [ 36-39 ] ."
31077706
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"Previous work by us and others has shown that hH1 current is increased by activation of PKA [10,24]."
11334883
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"PKA dependent modulation of NaV1.2 channels is voltage dependent in the range of -110 to -70 mV and is synergistic with phosphorylation by protein kinase C (16,17)."
17118799
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"For example as noted above, we have shown that PKA activation increases trafficking of hH1 into the plasma membrane [10]."
11334883