IndraLab

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PKA activates SCN5A. 5 / 5
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"Furthermore, it was shown that a cocktail of inflammatory mediators containing bradykinin, PGE-2, histamine, 5-HT, and adenosine 5 -triphosphate altered the gating properties of Nav1.5 and both protein kinase A and protein kinase C mediated the inflammatory mediators induced alteration in the gating properties of Nav1.5 [24] ."
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"For example as noted above, we have shown that PKA activation increases trafficking of hH1 into the plasma membrane [10]."
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"These were used to localize the structural determinant in the hH1 sequence responsible for PKA modulation of hH1."
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"Previous work by us and others has shown that hH1 current is increased by activation of PKA [10,24]."
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"Several studies have reported that cAMP and PKA directly modulate NaV1.5 and thereby INa density [ 36-39 ] ."
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