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Cycloheximide inhibits JUN. 3 / 3
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"However, the same concentration of cycloheximide (30 pglml) that did not inhibit induction of DNA binding activity completely inhibited Jun and AP-I synthesis."
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"In addition, nuclear cyclic AMP responsive element (CRE) - and activator protein 1 (AP-1) DNA binding activities were increased 2 h after K+ and serum withdrawal, and these increases were inhibited by cycloheximide, Ac-DEVD-CHO and PACAP 38."
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"When protein stability is considered, HE-145 was not able to accelerate degradation of preexisted c-jun protein when newly protein synthesis was inhibited by cycloheximide ( Fig. 5 C)."
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