IndraLab

Statements

USP18 inhibits Leukemia. 4 / 4
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"We next examined whether targeting Usp18 can suppress established leukemia, which better represents how a therapy would be applied in a clinical setting."
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"Since AML levels (GFP) were restored by Plk2 inhibition and the LSC-like population was most reduced by Usp18 depletion in leukemic mice, we hypothesize that Plk2-mediated pyroptosis contributes to LSC reduction in Usp18-depleted leukemia."
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"Finally, to test whether atypical ISG expression can be regulated by similar epigenetic machinery in Usp18 depleted murine leukemia cells in vivo as in the human cell line context, we also performed paired ATAC and RNA-seq using Usp18 and Usp18 murine leukemia cells."
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"Importantly, we also validated the biological effect of Plk2 in WT and Usp18-depleted leukemia cells in vivo."
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