IndraLab

Statements

ALG10B inhibits KCNH2. 3 / 4
| 3
reach
"Another recent study has shown that KCR1, a plasma membrane-associated protein that can be immunoprecipitated with hERG, reduces the sensitivity of hERG to blockers ( Kupershmidt, Yang, & Hayashi, 200[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16289936
reach
"Functionally, KCR1 reduces the sensitivity of HERG to classic proarrhythmic HERG blockers (sotalol, quinidine, dofetilide) in both cardiac and noncardiac cell lines."
14525949
reach
"We propose that KCR1, when coupled to HERG, may limit the sensitivity of HERG to proarrhythmic drug blockade and may be a rational target for modifying the proarrhythmic effects of otherwise clinically useful compounds."
14525949