IndraLab

Statements

ALG10B inhibits KCNH2. 3 / 4
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"We propose that KCR1, when coupled to HERG, may limit the sensitivity of HERG to proarrhythmic drug blockade and may be a rational target for modifying the proarrhythmic effects of otherwise clinically useful compounds."
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"Another recent study has shown that KCR1, a plasma membrane-associated protein that can be immunoprecipitated with hERG, reduces the sensitivity of hERG to blockers ( Kupershmidt, Yang, & Hayashi, 200[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Functionally, KCR1 reduces the sensitivity of HERG to classic proarrhythmic HERG blockers (sotalol, quinidine, dofetilide) in both cardiac and noncardiac cell lines."
14525949