IndraLab

Statements

USP1 decreases the amount of FANCD2. 4 / 4
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"We found that USP1 inhibition by SJB increased the levels of both Ub-FANCD2 and Ub-FANCI in MM cells."
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"Small molecule inhibitors of Usp1 may enhance FANCD2-Ub levels and TAp63 levels and perhaps promote cellular senescence."
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"The deubiquitinating enzyme, USP1, limits the cellular levels of Ub-FANCD2 ( Nijman et al., 2005a )."
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"USP1 levels decrease after DNA damage, leading to a transient elevation of Ub-FANCD2 levels and to increased DNA repair ( Nijman et al., 2005a )."
18082604