IndraLab

Statements

USP4 deubiquitinates RIPK1. 5 / 6
1 | 5
reach
"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
38716888
reach
"Given the deubiquitinating K63-linked ubiquitination function of USP4, receptor-interacting protein 1 can be deubiquitylated and inactivated by USP4 and then promotes tumor necrosis factor-α induced a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33038351
reach
"In head and neck squamous cell carcinoma, USP4 inhibits carcinogenesis by deubiquitinating receptor-interacting protein 1 (RIP1) and promoting apoptosis induced by tumour necrosis factor-α (TNF-α) (48)."
36969062
reach
"USP4 WT remarkably decreased polyubiquitination of RIP1 with and without TNF-α stimulation and USP4-C311S mutant failed to do so ( Fig. 4 A), indicating USP4 has the deubiquitination ability towards R[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23313255
reach
"As shown in Fig. 4 D, USP4 knockdown greatly increased TNF-α-induced polyubiquitination of RIP1."
23313255