IndraLab

Statements

USP7 activates PPARG. 7 / 10
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"Herpesvirus associated ubiquitin specific protease (HAUSP) modulates peroxisome proliferator activated receptor gamma (PPARgamma) stability through its deubiquitinating activity."
24072712
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"Quantitative RT-PCR analysis showed that HAUSP increased the transcript levels of PPARgamma target genes in HepG2 cells, resulting in the enhanced uptake of glucose and fatty acids, and vice versa, upon siRNA knockdown of HAUSP."
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"Additionally, USP7 overexpression upregulated PPARG mRNA in HepG2 hepatocytes, which was followed by increases in glucose and fatty acid uptake [100]."
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"HAUSP, but not the catalytically inactive HAUSP C223S mutant, increased the stability of both endogenous and exogenous PPARgamma through its deubiquitinating activity."
24072712
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"HBX 41,108, a specific inhibitor of HAUSP, abolished the increase in PPARgamma stability induced by HAUSP."
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"HAUSP enhanced the transcriptional activity of both exogenous and endogenous PPARgamma in luciferase activity assays."
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"Several ubiquitin ligases, such as FBOX9 and Cul4B, and an ubiquitin specific protease (HAUSP) targeting PPARgamma have been identified, and an increase in PPARgamma stability generally promotes PPARgamma activity and adipogenesis XREF_BIBR - XREF_BIBR."
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