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Celastrol inhibits NFKB1. 4 / 4
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"Finally, drugs that can potentially accelerate or attenuate aging include celastrol, which was reported to indirectly inhibit NFKB signaling [XREF_BIBR, XREF_BIBR], and radicicol, which is potentially a HSP90 and topoisomerase inhibitor [XREF_BIBR]."
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"Celastrol induces NQ01 and inhibits NFkB."
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"At the same time, celastrol inhibits the activities of other transcription factors, including androgen receptors (Hieronymus et al. 2006), glucocorticoid receptors (Trott et al. 2008), and NF-KB (Sethi et al. 2007)."
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"We have recently shown that either the induction of Hsp70 via pharmacological inhibition of NFkB by celastrol, or addition of exogenous recombinant human Hsp70 offers protection against oxidative stress and suppresses inflammation in RPE cells."
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