IndraLab

Statements

Celastrol inhibits NFKB1. 3 / 3
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"Finally, drugs that can potentially accelerate or attenuate aging include celastrol, which was reported to indirectly inhibit NFKB signaling [XREF_BIBR, XREF_BIBR], and radicicol, which is potentially a HSP90 and topoisomerase inhibitor [XREF_BIBR]."
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"We have recently shown that either the induction of Hsp70 via pharmacological inhibition of NFkB by celastrol, or addition of exogenous recombinant human Hsp70 offers protection against oxidative stress and suppresses inflammation in RPE cells."
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"We also found that celastrol inhibited the Akt and GSK3beta and Akt and NFkB survival pathway."
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