IndraLab

Statements



reach
"For example, downregulation of the expression of USP25 [35] in placental villus tissue of patients with RM inhibits the invasion and metastasis of trophoblast cells."

reach
"USP21 is upregulated in renal cell carcinoma tissues and cell lines, and depletion of USP21 inhibits cell proliferation and invasion through binding to the IL-8 promoter region and mediating transcriptional initiation 22."

reach
"It is reasonable that miR-27a-3p-mediated downregulation of USP25 contributes to the epithelial-to-mesenchymal transition, thereby inhibiting the migration and invasion of trophoblast cells via facilitating the Wnt pathway and regulating the miR-27a-3p/ATF3 axis [65,66]."

reach
"More important, the transwell experiment showed that overexpression of MDM2 could at least partially offset the invasion inhibition effect induced by USP25 knockdown ( Fig. 6 C)."

reach
"Knockdown of USP21 decreased the cell growth, invasion and cancer stem cell percentage of 786-O cells."

reach
"Knockdown of USP21 decreased the cell growth, invasion and cancer stem cell percentage of A-704 cells."

reach
"USP25 is suppressed by miR-200c, leading to inhibition of tumor cell migration and invasion in vitro and inhibition of lung metastasis formation in vivo ( Li et al., 2014a )."

reach
"Knockdown of USP25 by siRNA in A549, H1299, and SPC-A-1sci cells inhibited cell migration and invasion in vitro, which fell to levels similar to those observed after transfection with the miR-200c mimics."

reach
"A similar result was found in another study that increasing the expression of miR-27a-3p in the placental villus tissue of patients with RM downregulated ubiquitin-specific protease 25 (USP25), which contributes to the epithelial-to-mesenchymal transition (EMT) process, thus, suppressing the migration and invasion of trophoblast cells [65]."

reach
"The miR-27a-3p/USP25 axis was observed to inhibit trophoblast migration and invasion in the pathogenesis of RSA (Zhao et al., 2017)."

reach
"Knockdown of USP21 in TNBC cells inhibited cell proliferation, migration and invasion."

reach
"In addition, downregulation of USP21 inhibited proliferation, migration, invasion, and stemness profiles of nasopharyngeal carcinoma cells."