IndraLab

Statements

USP28 deubiquitinates FOXM1. 4 / 4
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"USP28 deubiquitinates and stabilizes the forkhead box M1 (FOXM1) transcription factor, which, in turn, activates the Wnt/β-catenin pathway and subsequently the expression of many EMT-related genes [146,195]."
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"Additionally, two other studies demonstrated that deubiquitylation and stabilization of FoxM1 by USP5 and USP28 contribute to its nuclear accumulation, which facilitates the recruitment of β-catenin to the Wnt target gene promoter and activates the Wnt signaling pathway (Chen et al., 2016; Chen L. et al., 2021)."
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"USP28 deubiquitinates and stabilizes FOXM1, which subsequently leads to the activation of the Wnt/β-linked protein pathway and promotes the progression of pancreatic cancer [110]."
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"Interestingly, another study found that USP28 can deubiquitinate and stabilize FOXM1, thus promoting cell proliferation through the Wnt/β-catenin pathway (Chen et al., 2021a)."
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