IndraLab

Statements

OTUB1 activates HYCC1. 13 / 13
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"OTUB1 overexpression significantly accelerated HCC cell proliferation and invasion as RACK1 did; OTUB1 overexpression lost stimulation upon the RACK1-deficient HCC cells."
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"Therefore, OTUB1 significantly increased multiple oncogenes expression and activated PI3K/AKT and FAK/ERK signaling in a RACK1-dependent manner in HCC."
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"To investigate the mechanism behind the HCC-enhancing effects of OTUB1, we adopted mass spectrum detection for OTUB1-interacted proteins in HCCLM3 and Huh7 cells (Fig. 4a)."
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"Immunoblotting showed that OTUB1 overexpression enhanced RACK1 and led to the activation of the Akt and ERK/FAK pathways in HCC cells."
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"OTUB1 has been proposed to promote the progression of myeloma (24), colorectal (9), prostate cancer (10), ovarian cancer (28), gastric cancer (12), HCC (12), and glioma (15) by facilitating tumor invasiveness."
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"In addition to melanoma, OTUB1 is highly expressed in HCC (13); however, the inhibition of OTUB1 expression reduced the progression of HCC."
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"Moreover, the knockdown of RACK1 reversed the overexpression of OTUB1-induced migration and invasion of HCC cells (Fig. 7b, d, g)."
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"OTUB1 significantly promoted the proliferation and migration of HCC cells in vitro."
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"In accordance with prior research, we discovered that OTUB1 increased HCC proliferative, migratory, and invading activity both in vitro and in vivo."
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"To determine whether OTUB1 accelerated the development of HCC by modulating RACK1 expression, we loaded siRACK1 into the OTUB1-overexpressed HCC cells and detected the characteristics then."
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"Colony-formation assay, EDU assay, and CCK8 assays indicated the suppression of RACK1 partly decreased the HCC cell proliferation caused by OTUB1 overexpression (Fig. 7a, c, e, f, h)."
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"Collectively, these findings Illustrated OTUB1 stimulated HCC growth and metastasis in vivo as indicated in vitro."
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"OTUB1 was broadly elevated in HCC tissues and promoted the proliferation and metastasis of HCC in vitro and in vivo."
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