IndraLab

Statements

Taxifolin inhibits KCNH2. 7 / 7
| 7
reach
"To determine whether taxifolin glycoside would block hERG K + channels, we recorded hERG K + currents using a whole-cell patch clamp technique."
23440017
reach
"In this study, we found that taxifolin glycoside directly inhibits hERG K + currents in a concentration dependent manner, with an EC 50 of 9.6 +/-0.7 microM."
23440017
reach
"The present study demonstrated that taxifolin glycoside directly blocks hERG K + channels in hERG-CHO cells."
23440017
reach
"We found that taxifolin glycoside directly blocked hERG K + current in a concentration dependent manner (EC 50 = 9.6 +/-0.7 microM)."
23440017
reach
"These data indicate that the activation of hERG K + channels was accelerated by taxifolin glycoside and that taxifolin glycoside may block the hERG K + channel when it is open."
23440017
reach
"In conclusion, taxifolin glycoside inhibited hERG K + currents that function by facilitating activation and inactivation process."
23440017
reach
"However, taxifolin glycoside of high concentration (more than 100 microM) did not produce further decrease of hERG K + currents."
23440017