IndraLab

Statements

reach
"Furthermore, SP600125 also significantly inhibited secretion of IFN-beta (XREF_FIG) suggesting that Poly I : C induced IL-1beta, TNFalpha, IL-12p70 and IFN-beta production in keratinocytes is mediated by JNK signaling pathway."
20728939
reach
"In this study, JNK inhibitor SP600125 prevented the upregulation of IL-1beta, TNFalpha, IL12p70 and IFN-beta upon stimulation with Poly I : C, suggesting that intracellular signaling by the JNK pathway contributes to regulation of proinflammatory cytokines and type I IFN."
20728939
reach
"However, the SP600125 treatment reversed this phenomenon of IFN-β at the late time point of CHv infection, indicating that inhibiting the activation of the JNK pathway will be beneficial to the regulation of the IFN signaling pathway under virus infection.Next, we explored the impact of the JNK pathway on viral replication."
35837399