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USP3 activates TP53. 2 / 2
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"We found that overexpression of USP3 greatly suppressed p53 protein degradation comparing to control cells ( Fig. 2 g)."

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"These results suggest that USP3 enhances p53 protein stability.Because USP3 stabilizes p53 protein, it is possible that p53 is the substrate of USP3."