IndraLab

Statements



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"In addition to mutations, UCH-L1 is a major contributor to idiopathic AD and PD [XREF_BIBR]."

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"Recently, a group showed that the introduction of UCH-L1 rescued the synaptic and cognitive function of AD model mice ( Gong et al., 2006 )."

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"The levels of UCHL1 were decreased in sporadic AD patients, and the overexpression of UCHL1 rescued the synaptic and cognitive function in AD model mice."

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"34 UCHL1 is also required for normal synaptic function and rescues Abeta related synaptic dysfunction in transgenic AD mice."