IndraLab

Statements

OTUD7B activates SQSTM1. 3 / 3
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sparser
"OTUD7B directly interacts with IRF3 and activates p62 by removing K63 polyubiquitin chains leading to enhanced p62 oligomerization."
38660307
sparser
"The deubiquitinating enzyme OTUD7B activates IRF3-associated SQSTM1 by removing its K63-linked polyubiquitin chains, leading to the increased activation of SQSTM1 to promote IRF3 degradation [ 13 ]."
35914352
reach
"Strikingly, the OTUD7B defect promoted the association of LSD1 with p62 and targeted LSD1 for p62-mediated proteasomal degradation, thereby eliminating breast cancer metastasis."
38572094