IndraLab

Statements

USP12 binds HMGB1. 7 / 7
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reach
"Recently, it was reported that USP12, another USP family member, is highly expressed in multiple myeloma cells and binds to HMGB1 to deubiquitinate and stabilize HMGB1, resulting in the promotion of pro-survival autophagy in myeloma (Li et al. 2022)."
36585612
biogrid
No evidence text available
34997217
biogrid
No evidence text available
34997217
biogrid
No evidence text available
34997217
biogrid
No evidence text available
34997217
sparser
"In the context of autophagy, the study of multiple myeloma (MM) showed that USP12 could interact with the key autophagy mediator HMGB1 (high mobility group box-1) protein to deubiquitinate and stabilize it [ xref ]."
37752518
sparser
"This suggests that targeting the USP12-HMGB1 axis could have therapeutic potential in human myeloma [ 80 ] ( Fig. 2 A)."
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