IndraLab

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USP2 activates inflammatory response. 5 / 6
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"Meanwhile, Usp2-overexpressed hepatocytes displayed aggressive inflammation, as evidenced by increased production of inflammatory cytokines IL-1β, IL-6, and TNF-α (Fig. 5F)."
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"Collectively, these data suggest that USP2 in myeloid cells promotes colon inflammation after DSS treatment.2.3 Knockout of USP2 alters gene expression profile in myeloid cells after DSS treatment."
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"USP2 may also mediate the response of the clock to inflammation, as the expression of the gene is increased in response to TNFalpha treatment, and CRY1 protein induction in response to this cytokine is abrogated when Usp2 expression is knocked down."
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"In macrophages, USP2 promotes inflammation by activating the nuclear factor kappa B (NF-κB) pathway17, 18."
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"In addition, results from Masson trichromatic staining showed that collagens (major components of ECM in the gut) (Rieder et al., 2013) accumulated more intensively in the colon tissues from Usp2 mice than Lyz2-Cre;Usp2 mice after colitis induction (Fig. 5D), indicating that knockout of USP2 impairs the ECM remodeling in the colon inflammation."
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