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USP7 inhibits CRY1. 1 / 2

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"Using cells stably expressing luciferase under a circadian promoter, we observed that activation of AMPK increased the circadian period as expected, inhibition of Hausp also increased period, and combined activation of AMPK and inhibition of Hausp led to a dramatic increase in period, perhaps reflecting synergistic destabilization of nuclear Cry1 (XREF_FIG)."

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IndraLab

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USP7 inhibits CRY1. 1 / 2

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