IndraLab

Statements

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione inhibits NFKB1. 2 / 2
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"However, how TQ manifests these activities is not fully understood, although it has been shown to downregulate the expression of Bcl-xL [XREF_BIBR], COX-2 [XREF_BIBR], iNOS [XREF_BIBR], 5-LOX [XREF_BIBR], TNF [XREF_BIBR] and cyclin D1 [XREF_BIBR], all known to be regulated by NFkB activity that can be blocked by TQ [XREF_BIBR]."
28415607
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"Although further demonstrations are necessary, inactivation of KIT and FLT3 signaling by TQ may occur via their gene downregulation resulting from TQ disrupted Sp1 and NFkB functions."
28415607