IndraLab

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USP10 activates Histone. 3 / 3
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"To test whether USP10 targets histones as substrates, we co-expressed Flag tagged USP10 (Flag-USP10) with tagged H2A.Z or H2A in 293T cells and measured the levels of ubiquitylated histones by Western blot."
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"Importantly, increased USP10 expression did not affect the levels of endogenous H2Bub1 (XREF_FIG B), indicating that USP10 specifically targets the H2A family of histones."
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"Supporting our finding that USP10 targets histones, cells with stable knockdown of USP10 consistently have higher levels of H2A.Zub1 and H2Aub1, whereas the levels of H2Bub1 remain unchanged (XREF_FIG D)."
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