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(E)-3-tosylacrylonitrile inhibits RELA. 3 / 3
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"In Trxlpi -infected HEK293 cell, pre-treatment and maintenance in BAY-11-7082, an inhibitor of the inhibitor of NF-κB kinase (IκB) [ 51 ], restored cytoplasmic p65 to the WT levels ( Fig. 5 A & B)."
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"We also establish that the small molecule BAY-11-7082 causes a dose dependent inhibition of p65 as well as p50TAD dependent transactivation."
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"BAY11-7082 ( an inhibitor of NF-kappaB ) inhibited the NF-kappaB ( p65 ) expression and prevented the increase of NOX4 expression and ROS production induced by TGF-beta ( P < 0.001 ) , which has also verified reduced TGF-beta induced cell migration by inhibiting the EMT process , and also reduced cell proliferation of A549 cells ( P < 0.001 ) ."
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