IndraLab

Statements


CYLD activates RAB7A. 2 / 2
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"CYLD inactivates mechanistic target of rapamycin complex 1 (mTORC1) reactivation, upregulates Ras genes from rat brain 7 (Rab7) and enhances cardiomyocyte death in pressure overloaded hearts.."

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"In addition, Cyld gene gain- and/or loss-of-function approaches in vitro and in vivo demonstrated that CYLD mediated cardiomyocyte death associated with impaired reactivation of mechanistic target of rapamycin complex 1 (mTORC1) and upregulated Ras genes from rat brain 7 (Rab7), two key components for autolysosomal degradation."