IndraLab

Statements

SCN8A inhibits NFkappaB. 4 / 4
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"MED inhibits ox-LDL induced activation of NF-kappaB signaling in macrophages."
26045945
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"To explore whether MED could inhibit NF-kappaB signaling, the effects of MED on ox-LDL-induced NF-kappaB activation in RAW 264.7 cells were examined."
26045945
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"In this study, we showed that MED could inhibit receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation and the expression of three well-known osteoclast markers such as tartrate resistant acid phosphatase, calcitonin receptor, and cathepsin K in bone marrow derived macrophages."
22678021
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"MED inhibited LPS induced nuclear translocation of nuclear factor (NF)-kappaB (NF-kappaB) p65, IkappaB degradation, IkappaB kinase (IKK) phosphorylation, and the activation of extracellular signal regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38, suggesting that MED blocks the activation of both NF-kappaB and mitogen activated protein kinase (MAPK) pathways."
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