IndraLab

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"After 3 hours, saturating concentrations (10 μg/ml) of anakinra were added to the cells to block further IL1R signaling, and endpoint supernatants were collected at 24 hours."

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"Anakinra, a human IL-1R antagonist, blocks the IL-1R to inhibit the activities of IL-1α and IL-1β."

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"Alternatively, IL1RN genetic variants may decrease the ability of IL-1Ra to competitively inhibit proinflammatory IL-1beta production during an inflammatory immune response, with IL-1beta ultimately influencing timing of birth."

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"In recent years, clinical studies have found that blocking IL-1 is beneficial for IHD and can also improve cardiac remodeling in patients with STEMI, among which the IL-1R antagonist anakinra has been more thoroughly studied [97]."

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"At present, NLRP3-mediated diseases, such as rheumatoid arthritis, are currently managed with biologics targeting IL1β signaling, such as the IL1R antagonist anakinra (31, 32)."

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"These data indicated that the IL-1R1 antagonist Anakinra inhibited IL-1β-mediated HOXC10 upregulation and HCC invasion and metastasis."

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"These findings extend previous results reported in related in vitro settings where the IL-1R antagonist Anakinra was shown to suppress rhinovirus induced cytokine release from human primary epithelial[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"TLR4 mice were treated with rIL-1RA (anakinra, Amgen) to block IL-1R activation."

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"Interestingly, the IL1R antagonist IL1RN was also one of the most highly upregulated genes in macrophages from Superexpanded LOAD samples (Supplementary Figure 4G) which may help to restrain IL1B-mediated effects on CD8 T cell proliferation in AD."

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"Remarkably, rheumatoid arthritis patients that received the IL-1R antagonist Anakinra exhibited a roughly 330-fold increased rate of invasive GAS infections which included an elevated likelihood of life-threatening complications such as necrotizing fasciitis and sepsis [95]."

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"It has been reported that the IL1R antagonist anakinra could be used to prevent the development of vincristine-induced mechanical hyperalgesia (15)."

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"14 During the COVID-19 epidemic, anakinra is commonly used as an immunotherapy to suppress IL-1R."

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"IL-1R1 is located on the membrane surface, thus, icIL-1RA would require secretion into the extracellular space for it to block IL-1R1, although IL-1R1 intranuclear localization in oral dysplastic and cancer cells has been recently described [65]."

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"39 The IL-1R antagonist anakinra was approved for severe COVID-19 by the European Medicines Agency39 while the United States Food and Drug Administration had issued an Emergency Use Authorization (EUA) for the emergency use of anakinra for hospitalized adults with COVID-19 pneumonia requiring supplemental oxygen who were at risk of progressing to severe respiratory failure and likely to have an elevated plasma soluble urokinase plasminogen activator receptor.40 Although this suggests the pathogenetic role of IL-1β in COVID-19, our findings imply that IL-1β and IL-1R1 could serve as molecules that mediate an interaction between myeloid cells, including monocytes and macrophages, and CD4 Th cells for the development of adaptive immune responses to SARS-CoV-2."

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"Diagnosed via bone marrow biopsy, he was treated with corticosteroids and the IL-1R antagonist anakinra, leading to recovery."

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"The patient was started on a steroid taper (8-week taper per the HLH-94 protocol), IL-1R antagonist anakinra, and atovaquone for pneumocystis pneumonia prophylaxis."

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"Furthermore, patients with grade 3 or 4 CRS should be transferred to intensive care for continuous monitoring, management of arrhythmias and circulatory shock, and provision of noninvasive positive pressure or mechanical ventilation as needed.Preclinical studies have demonstrated the utility of the IL-1R antagonist anakinra alone and in combination with tocilizumab in the management of CAR T-cell therapy–associated CRS.22 Case reports have also demonstrated its utility in patients with multiple myeloma receiving anti-BCMA CAR T-cell therapy."

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"These findings along with the promising therapeutic achievements in COVID-19 which obtained by IL-1R antagonist Anakinra [144] and Cytosorb [145] suggested that targeting the IL-6 axis may benefit sev[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Blocking IL-1β also helped to reduce tumor progression, but combining IL-1α/IL-1β blockade or targeting them both using the IL-1R1 antagonist anakinra most effectively disrupted tumor initiation."

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"In ASFV-infected cells, IL-1R antagonist (IL-1RN), a natural IL-1 antagonist, increases significantly and inhibits the combination of IL-1 with IL-1R, which competitively inhibits the effect of IL-1."

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"To determine the functional relevance of this, we then performed antibody-based blockade of IL-1α and/or IL-1β and compared these therapies with the IL-1R1 antagonist anakinra, which would interfere with IL-1α and IL-1β signaling simultaneously."

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"Currently, the soluble decoy receptor rilonacept, the IL-1R antagonist anakinra, and neutralizing monoclonal anti-IL-1β antibody canakinumab have been investigated against IL-1β-mediated neuroinflammation and AD [165, 166]."

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"They found a clinical improvement and a normalization of IL-1, IL-6 and IL-18 plasma levels, suggesting that anakinra acts as an inflammation regulator blocking IL-1R signaling, but also restores the IL-18-NK cell route."

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"Further, polymorphisms in the gene encoding IL-1Ra, IL1RN, that reduce the production of IL-1Ra lead to an increase in the IL-1ɑ/β:IL-1Ra ratio, resulting in increased pro-inflammatory signaling, and an increased risk of stillbirth (Gerber et al., 2005)."

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"Before analysis, we treated the cells overnight with either IL-1β or the IL-1R antagonist Anakinra (Fig. 7A, B)."

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"Anakinra is a protein antagonist of IL-1R, upregulation of which promotes the progression of ALI [31] ."

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"We demonstrate that IL-1β treatment alone suppresses the mitochondrial ATP production in a kidney cell line, while Anakinra-mediated inhibition of IL-1R signaling, caused increased oxidative phosphorylation."

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"The IL1RN is the antagonist of IL1R1 whose gene expression was higher in the Ct and the T2 cell than in the A3 cell line."

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"IL-1R antagonist Anakinra (IL-1RA, #407616) was obtained from Calbiochem; Anakirna (C H N O S ) is a recombinant biopharmaceutical and slightly modified version of the human interleukin 1 receptor antagonist protein-IL-1RA."

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"The IL-1R antagonist anakinra, approved for the treatment of rheumatoid arthritis, has been proposed to prevent autoimmune beta-cell destruction in patients with T1D."

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"In another study, the IL-1R1 antagonist Anakinra was shown to reduce the number of mice with bone metastases caused by osteotropic MDA-MB-231 cells, possibly through reduction in angiogenesis and tumor growth within the bone microenvironment [77]."

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"IL-1R can be activated by IL-1alpha and IL-1beta , and can be blocked by anakinra , whereas canakinumab can be used to prevent IL-1beta binding to IL-1R ."

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"In both studies, the use of the IL-1R antagonist anakinra alone and in combination with tocilizumab counteracted CAR-T CRS, leading to increased overall survival more effectively than the anti-IL6 alone."

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"Of note, the recombinant IL1R1 antagonist Anakinra is being evaluated in PDAC clinical trials, in combination with standard chemotherapy (NCT02021422, NCT02550327, NCT04926467)."

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"Endogenous IL-1Ra inhibits the IL-1R1, the functional receptor for IL-1 ( Avital et al., 2003; Vezzani et al., 2000b ), thus reducing the pro-inflammatory cascade and reducing neuropathology."

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"Given this amplification, treating DOCK8-deficient humans with an IL-1R antagonist, such as Anakinra, may be beneficial in abrogating symptoms in those with severe allergies."

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"IL-1R antagonist anakinra, which is FDA-approved for the treatment of rheumatoid arthritis and neonatal-onset multisystem inflammatory disease, has also been under trial for multiple cancers, and outcomes are awaited.Siltuximab (anti-IL-6 antibody) showed promising preclinical results in the xenograft cholangiocarcinoma model [110] but did not achieve an impressive outcome in multiple myeloma clinical trials in combination with bortezomib [111]."

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"Zhou et al demonstrated that suppressing IL-1 signalling with the IL1β-specific blocking antibody Canakinumab, or the IL1R1 antagonist Anakinra, could effectively eradicate breast cancer-induced bone metastasis.82 Canakinumab has shown effects in reducing lung cancer incidence in a clinical trial,83 84 and a phase I clinical trial involving Anakinra for rectal cancer has been initiated.85 Moreover, it has been revealed that IL6 inhibitors, such as siltuximab (anti-IL6 mAb) and tocilizumab (an anti-IL6R mAb), are effective in multiple clinical cancer treatments, including myeloma, metastatic renal cell carcinoma and prostate cancer.8689 Alternatively, Mac-1/ICAM1 inhibitors A-20580481 and Vcam1/VLA-4 antagonist natalizumab may be applied to disrupt the formation of CTC-neutrophil clusters.90 CTC-platelet cluster."

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"Because autocrine IL-1R signaling is a critical component that drives the canonical NF-kb cascade in PDAC, the combination of the IL-1R antagonist Anakinra with nab-paclitaxel, gemcitabine, and cisplatin has been opened in a pilot clinical trial for patients with resectable or potentially resectable PDAC (NCT02550327)."

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"Notably, the gut pathology of mice transferred with Kaede-Red+CD3 CD4 T cells was significantly attenuated by treatment with the IL-1R antagonist anakinra (Figures 6L–6O)."

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"The marketed drug IL-1R antagonist Anakinra is currently under investigation in clinical trials for MS (NCT04025554; ref."

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"We hypothesize that deletion of Il1rn induces a tonic activation of IL-1R1 signaling in presynaptic axon terminals, mediating the observed increase in action potential dependent GABA release."

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"The IL-1R antagonist anakinra (50 mg/kg) or saline was i.p."

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"Notably, the IL-1R antagonist anakinra was found to be effective in inhibiting ESCC proliferation as well as lymph node metastasis."

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"Future treatment to consider are IL-1R antagonist anakinra, fecal transplantation [84], DUR-928 [85], and IL-22 agonist F-652 [86]."

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"Moreover, IL-1R antagonist anakinra (232, 233) and IL-1 inhibitor rilonacept (234, 235) can also be used as effective treatments in sJIA."

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"These findings along with the promising therapeutic achievements in COVID-19 which obtained by IL-1R antagonist Anakinra [144] and Cytosorb [145] suggested that targeting the IL-6 axis may benefit severe COVID-19 patients through the improvement of NK cell functional activity."
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"IL-1α and IL-1β bind to the same receptor, i.e., type 1 IL-1 receptor (IL-1R1), to activate the downstream signaling, whereas IL-1Ra inhibits IL-1R1 in a competitive binding manner."

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"These pro-metastatic effects of IL-1B were confirmed in experiments where inhibition IL-1B or IL-6 with an anti-IL-1B antibody or IL-1R antagonist Anakinra attenuated EMT, migratory and invasive capabilities of the aforementioned tumour cells [4], [12]."

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"More importantly, the genetic deletion of Il-1r1 in Tet2-knockout HPSCs or the pharmacologic inhibition of IL-1β signaling by the Il-1r1 antagonist anakinra reduced myeloid expansion and clonal evolution ."

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"Most patients do not show clinical improvement upon treatment with the IL-1R antagonist anakinra or corticosteroids, but are successfully treated with the TNF-blocking agents infliximab or etanercept,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Previously, it was shown that IL-1R signalling deficiency or blockade with the IL-1R antagonist anakinra protects from pulmonary hypertension and fibrosis [9–11]."

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"Interestingly, in CAFs with already a basal activation of the NFκB pathway, the addition of the IL1R1 antagonist Anakinra to untreated CAFs reduced the nuclear presence of p65 and thereby the activation of the NFκB pathway, supporting the existence of an IL-1-driven autocrine loop in CAFs, which potentially helps maintain the pro-tumorigenicity of these cells (Supplementary Fig. 4h)."

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"10 A larger multicentre study on the effect of the IL-1R antagonist anakinra in patients with STEMI is ongoing."

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"However, mitigation of CAR-T related neurotoxicity with tocilizumab is ineffective, possibly due to its exclusion from the CNS by the blood–brain–barrier [ 4 ], and recently the IL1R antagonist anakin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Canakinumab, a monoclonal antibody that targets IL-1β, has shown efficacy in a patient who experienced hypersensitivity to the IL-1R antagonist anakinra."

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"The conditioned medium from PA-stimulated Hepa1-6-shSLC7A11 cells was used to culture BMDMs and simultaneously gave cells anti-IL-1β or IL-1R1 antagonist anakinra."

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"This activation is blocked by administration of the IL-1R blocker anakinra."

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"The IL-1R antagonist Anakinra has been demonstrated to effectively treat cryopyrin-associated periodic syndrome, an autoinflammatory syndrome [9] , and acute gout flares [10,11] ."

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"Anti-IL-1 therapies, including Anakinra (an IL-1 receptor antagonist) and Canakinumab (an anti-IL-1β monoclonal antibody), competitively inhibit IL-1R1 or neutralize IL-1β, thereby reducing proinflammatory cytokine production and neutrophil infiltration."

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"Cumulatively, these results suggest that the absence of Il1r1 delays premalignant disease progression and mortality observed in Tet2-KO mice.We next examined whether treatment with an FDA-approved IL1R1 antagonist anakinra impedes Tet2-KO myeloid expansion in a competitive transplantation model (Fig. 5e)."

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"For example, the IL-1R antagonists anakinra and canakinumab have been previously evaluated in hospitalized patients with COVID-19 but failed to show clinical efficacy [15, 63]."

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"The proinflammatory cytokine IL1β also might contribute to TAN accumulation, polarization, and survival in the TME.109 Here again, combining the anti-IL1β antibody canakinumab or the IL1R antagonist anakinra with ICIs in clinical trials might affect both IL1β-mediated cancer cell proliferation and TANs (table 1)."

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"These cells were treated with IL-1β alone or in combination of Anakinra (an inhibitor of IL-1R1), small inference RNA (siRNA) against IL-1R1, siRNA against c-FOS or NGF neutralising antibody."

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"In cell co-culture model, the expression level of Nrf2 and HO-1 was prominently upregulated and the level of NLRP3, caspase-1, and IL-1β significantly downregulated when IL-1R1 was inhibited by anakinra (Fig.  xref A, B)."

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"However, wild-type mice treated with the IL-1R antagonist anakinra are protected from C. difficile-toxin-induced intestinal injury ."

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"Pharmacological blockade of IL-1/IL-1R or IL-33/IL-33R interaction ameliorates experimental GvHD; however, a randomized trial failed to show any protective effect of the IL-1R antagonist Anakinra against clinical GvHD."

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"Similarly, there was no significant difference in the effect of treatment with the IL-1R antagonist Anakinra (1.5 mg/paw) between the depleted and control groups with respect to its ability to reverse mechanical or heat nociceptive sensitization (fig."

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"Among them, the IL-1R antagonist anakinra may be used to interfere in IL-1β signalling ( Abbate et al., 2020 )."

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"One medication that might modify the disease was identified: anakinra (an antagonist of IL1R1) ( Supplementary Table 6 )."

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"Shahzad et al. found db/db mice with T2DM to be protected from kidney disease by injecting the human recombinant IL-1R antagonist anakinra (18)."

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"Table 2 includes details of the anti-rheumatic drugs studied and/or suggested for use in COVID-19 treatment, and the molecular target of each one.According to Dimopoulos et al. (2020) [67] , the recom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"We have demonstrated that the accumulation of amyloid triggers lysosomal enlargement and reduces autophagosome fusion with lysosomes, thus impairing the autophagy flux, which in turn may exacerbate amyloid deposition in a vicious cycle.7 35 Moreover, amyloids trigger inflammatory cascades in MPS by triggering microglia and astrocyte activation, leading to a destructive neuroinflammatory environment.27 43 Of note, a recent clinical trial testing the anti-inflammatory IL-1R antagonist anakinra has shown significant improvement in multiple neurobehavioral domains of patients with MPS-III.55 Therefore, amyloid storage is a key factor underlying multiple deleterious mechanisms downstream of the primary enzyme defect and GAG storage in different neuronopathic MPSs.To date, targeting the secondary storage of toxic amyloidogenic proteins has only been explored for the treatment of neuronopathic MPS by our team."

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"In addition, the human IL-1R antagonist Anakinra inhibits both IL-1 and its receptor, IL-1R, reducing metastatic CRC [118]."

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"Early studies of diethylnitrosamine-induced HCC in mice have shown that IL-1α released by necrotic hepatocytes acts as an inflammatory switch that supports compensatory cell proliferation and HCC development, which could be counteracted using the IL-1R antagonist anakinra ."

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"Seropositive plasma impaired in vitro IL-1Ra bioactivity, which could be reversed by anakinra or canakinumab treatment."

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"In both studies, the inhibition of IL1R signaling with the IL1R antagonists anakinra or canakinumab prevented or reduced metastasis [56,57]."

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"Finally, the authors define the contributions of IL-6 and PDGF to the PH phenotype in the myelomonocytic Regnase-1 deficient mice by showing that treatment with either an IL-6 neutralizing antibody (MR16–1) or imatinib, a multi-kinase inhibitor of PDGFRβ, both partially attenuated the PH and vascular obliterative phenotype, while IL1R antagonist anakinra did not exert a significant impact."

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"It was also observed that NO production was significantly ( p < 0.05) decreased following S. aureus infection in peritoneal macrophages after separate neutralization of TNFR1 and IL-1R respectively by[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"The pro-inflammatory cytokine IL-1β exerts its biological activity through ubiquitously expressed IL-1RI, and a recent study suggested that IL-1RI in hepatocytes plays a pivotal role in mediating LPS/[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"In addition, another selective P2X7R antagonist A740003, and IL-1R antagonist anakinra also reduced AF inducibility in the SP model."

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"151 The IL-1R antagonist anakinra is linked to a reduced incidence of HF and HF-related hospitalization in patients with ST-segment elevation myocardial infarction."

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"XREF_BIBR The C allele of IL-1RN -1129 reduces IL-1RA, which is associated with an increased IL-1beta level that in turn inhibits gastric acid secretion."

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"Targeting of the IL-1 axis in gout, with initial clinical trials of the IL-1R antagonist Anakinra, has shown remarkable efficacy ( McGonagle et al., 2007, 2008; So et al., 2007 )."

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"Yin et al. previously demonstrated that a P2X 7 R antagonist in combination with the IL-1R antagonist anakinra was no more effective in reducing measures of systemic inflammation compared with adminis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"The IL-1R antagonist anakinra, IL-17 inhibitors, and pegylated interferon-λ1 are testable Food and Drug Administration-approved drugs predicted from this study to therapeutically mitigate the elevated systemic inflammatory response and associated cardiac dysfunction consequent to surgical repair of complex neonatal CHD."

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"Thus, the IL-1RA inhibition of IL-1R1 affects several immune factors."

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"Interestingly, ALDH and IL‐1 receptor (IL1R1) double‐positive CSCs are enriched following antiestrogen therapy and held responsible for the treatment failure in breast cancer patients, which can be attenuated with IL1R1 antagonists such as anakinra."

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"Our ongoing research aims to bridge this gap, enhancing the relevance and applicability of our murine model system to human BCC.Overall, the identification of TREM1+ myeloid-derived IL1 and OSM as sufficient to induce BIT and resistance generates a unique therapeutic opportunity to target BIT using currently available agents such as IL1R antagonist Anakinra or JAK inhibitors."

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"Furthermore, protective effects on neutrophilic inflammation and emphysema were seen after administration of the IL-1R antagonist anakinra ."

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"Spatial learning defects are also relieved when mice are treated with the IL-1R antagonist anakinra(Garber et al., 2018)."

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"Importantly, the clinically used IL1R antagonist anakinra prevented development of vincristine-induced gait abnormalities and mechanical allodynia without affecting the chemotherapy efficacy of vincristine—or tumor growth—in medulloblastoma patient-derived xenograft (PDX) models."

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"Most importantly, the administration of the IL-1R antagonist Anakinra reproduced the antifibrotic phenotype of IL-1R KOs."

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"Il-1R antagonists such as anakinra block activation of the Il-1R signaling pathway, thereby inhibiting the IL-1β pathway and inhibiting tumor growth [ 99 ]."

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"[25] the IL-1R antagonist Anakinra has also been shown to reduce the endothelial dysfunction in diabetic mice."

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"C3aR antagonist SB290157 (M8470) and IL-1R antagonist anakinra (M10139) were purchased by AbMole (Houston, USA)."

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"The IL1R antagonist anakinra prevents development of vincristine-induced mechanical allodynia and gait disturbances."

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"NLRP3-mediated diseases, such as familial cold autoinflammatory syndrome, are currently managed with biologics targeting IL-1β signaling, such as the IL1R antagonist anakinra."

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"IL-1 activity is mainly counterbalanced by the endogenous IL-1 receptor antagonist (IL-1Ra, gene name Il1rn), which competitively blocks IL-1R1 activation."

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"Herein, we present a 33-year-old man with COVID-19-related pericarditis (COVID-19-RP) who was unresponsive to colchicine and nonsteroidal anti-inflammatory drugs, but was successfully treated with the IL-1R antagonist anakinra."
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"In one such study, patients with CKD were treated with the IL-1R antagonist anakinra for 4 weeks, resulting in a significant reduction in hsCRP and IL-6 levels by 53% and 40%, respectively, compared with a placebo group."

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"The above data demonstrate that NLRP3-dependent IL-1β signaling mediates the symptoms of VIPN, including mechanical allodynia and gait disturbances, and that the IL1R antagonist anakinra can prevent these adverse effects."

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"The use of IL-1R1 antagonist anakinra can not only slow down the progression of lung cancer, but also normalize emergency myeloid cell generation in elderly mice, fundamentally eliminating immunosenescence [119]."

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"MCT cells were cultured in the presence of the IL1R antagonist IL-1Rn (100 muM) for 1 h and further incubated with 10 mug/ml CsA for 6 h. Mean +/- SD from three independent experiments."

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"The IL-1R1 antagonist anakinra prevented nephropathy in diabetic mice (160)."

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"Pharmacological treatment using IL-1R antagonist Anakinra improved pregnancy outcomes in an experimental mouse model [123]."

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"In cell co-culture model, the expression level of Nrf2 and HO-1 was prominently upregulated and the level of NLRP3, caspase-1, and IL-1β significantly downregulated when IL-1R1 was inhibited by anakinra (Fig. 8A, B)."

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"Furthermore, the IL-1R antagonist anakinra exhibited a nephroprotective effect in diabetic mice [100]."

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"Of note, because IL-1β and IL-1α both signal via the IL-1R, clinical studies using the IL-1R antagonist anakinra do not define which cytokine has pathogenic functions, and so we use the term IL-1 to i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Targeting the IL-1 family of cytokines, particularly the alpha and beta subunits, with the pharmacological IL-1r antagonist Anakinra, has substantially reduced inflammation in autoimmune disorders (C."

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"Although the functional role of IL-1 in central COVID-19-related neuropathologies remains unclear, improved clinical outcomes alongside reduced IL-6 and CRP levels after early treatment of patients with COVID-19 with the IL-1R1 antagonist anakinra suggest that this regimen might also be considered to alleviate symptoms in Neuro-COVID."

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"The presence of IL-1R on skin epidermal cells and the present finding of IL-1R antagonist anakinra blocking local SP-induced skin sensitization further support this notion."

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"Furthermore, the expression level of IL1R1 strongly correlates with increased neutrophils in sputum and airflow limitation of asthmatic patients and LPS-induced neutrophilic airway inflammation in healthy volunteers was attenuated by the IL1R1 antagonist anakinra ."

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"The IL-1R antagonist anakinra is efficacious in various autoinflammatory diseases, such as haemophagocytic lymphohistiocytosis, pointing to a prominent role of IL-1."

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"Indeed, IL-1 was shown to be a key factor for activation of TSLP secretion in both pancreatic (22) and breast cancer (21), where the use of the IL-1R antagonist anakinra reduced TSLP availability in vitro and in vivo."

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"Since blockade of IL-1R by anakinra reduced leukocyte levels in both HPV-positive and HPV-negative OPSCC in vitro, it could be argued that this antagonist may be effective for both types of tumour, however, the increased numbers of leukocytes recruited to HPV-negative OPSCC suggests that the treatment would be most effective for this cancer type."

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"Drugs of interest include Adalimumab, Infliximab and Etanercept that inhibit TNF-α, and Anakinra that inhibits IL-1 and IL-1Ra genetic therapy, that is in the preclinical stage on the animal model [77,239]."

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"IL1-R antagonists such as Anakinra may be beneficial in therapy [57]."

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"In some experiments, IL-1R antagonist Anakinra (100 ng/mL), anti-IL-1β mAb (150 ng/mL), anti-TNF-R1 (50 ng/mL) plus anti-TNF-R2 mAbs (50 ng/mL), STAT1 phosphorylation inhibitor SU6656 (150 µM), or IRF1 expression inhibitor cyanidin 3-O-glucoside chloride (C3G, 300 µM) were added to investigate the signaling pathways that engaged in the PTA-induced Th9 cells differentiation.For in vitro human Th9 cell polarization, the peripheral blood mononuclear cells (PBMCs) were isolated from NSCLC patients using 1×Ficoll and further purified by flow cytometry with the MojoSort Human CD4 T Cell Isolation Kit (BioLegend)."

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"Treatment of animals having had tibia fracture and cast immobilization with IL-1R antagonist anakinra reduces not only the CRPS-like nociceptive sensitization, but also levels of the pro-nociceptive mediators IL-6, tumor necrosis factor α and nerve growth factor in hindpaw skin (12)."

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"Anakinra blocks signaling of IL-1R, a receptor for both IL-1α and IL-1β (47)."

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"Currently, multiple clinical trials are targeting the IL-1 family in hematological malignancies [8,9], examining predominantly the therapeutic values of either anakinra (antagonist of IL-1R) or canakinumab (IL-1β-neutralizing monoclonal antibody) [8,9]."

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"Our results indicated that intracellularly survived bacterial count (766 ± 28.87) at 60 min was significantly increased ( p < 0.05) after dual blocking of anti -TNFR1 antibody and IRAP mediated neutra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Our interest in the potential role played by IL1β in mCRPC stems from our previous findings that the highly metastatic behavior of PC3-ML cells in preclinical models (13–17) could be dramatically mitigated by treatment with the IL1R antagonist anakinra (4)."

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"Canakinumab inhibits the NLRP3-inflammsome product, IL-1β, while Anakinra inhibits the IL-1β receptor (IL-1R)."
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"For example, in one experiment, Nf2 ;Cdkn2a mice were chronically exposed to asbestos in the presence or absence of the IL-1R antagonist anakinra."

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"The IL-1R antagonist anakinra or the IL-6R antagonist tocilizumab are used to treat rheumatoid arthritis ( Kishimoto, 2010 )."

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"Treatment of CRS with the IL-1R antagonist anakinra proved to be effective in both preclinical studies ."

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"On the other hand, the presence of the IL-1RN allele 2 was shown to be associated with enhanced IL-1beta production and decreased production of IL-1Ra in vitro [24]."

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"The IL-1R antagonist, Anakinra significantly inhibited IL-1β-induced p-NF-kB in the CCR6 + T cells and CD11c mDCs with a trending inhibition in CD14 monocytes and Lin -CD161 + CD25 + cells."
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"We also measured the effect of administration of the IL-1R antagonist anakinra on arterial pressure in DOCA-salt mice."

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"Additionally, C57/BL6 mice were treated with either the IL-1R1 antagonist Anakinra (n=7) or vehicle (n=8)."

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"IL-1R knockout mice and the IL-1R antagonist anakinra were used in two separate groups to suppress activation of IL-1R."

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"Anakinra antagonizes the effects of IL-1β by inhibiting IL-1R1, and MCC950 stimulates the blockade of these neuroinflammatory cascades by inhibiting NLRP3, which might suppress the headache."
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"The IL-1R antagonist Anakinra significantly inhibited IL-1β-induced p-NF-kB in the CCR6 + T cells and CD11c myeloid DCs (mDC) with only a trending inhibition in CD14 monocytes and Lin -CD161 + CD25 + cells."
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"To exclude that this effect was secondary to ASC and NLRP-3 dependent IL-1β activation, the transfected cells were treated with the IL-1R antagonist Anakinra."

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"IL-1RA competitively inhibits IL-1R, counteracting IL-1α ( xref ), while membrane-bound IL-1α induces chemokines and IL-6 via macrophages, creating a positive feedback loop ( xref )."

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"In addition, the development of drugs such as the IL-1R antagonist anakinra (Kineret®), rionacept (Regeneron®; IL-1 trap), and canakinomab (Ilaris®; anti-IL-1β antibody) also suggests that blocking IL-1β signaling may be a potential complementary therapy for allergic airway inflammation [82, 83]."

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"As the application of antagonist proteins, such as tocilizumab and anakinra, for blocking IL-6R and IL-1R ( Giavridis, et al., 2018 ; Kotch, et al., 2019 ; Norelli, et al., 2018 ), respectively, can o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"IL-1β signals via its main receptor (IL-1R), which can be blocked by the IL-1R antagonist anakinra, an FDA-approved drug for treating rheumatoid arthritis."

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"Co-injection of mice with anti-Col7 IgG and the IL-1R antagonist anakinra significantly reduced the induction of skin lesions [129]."

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"Additionally, the IL-1R antagonist anakinra shows frequently incomplete treatment response and IL-36 may be a more promising druggable target."

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"Moreover, the utilization of the IL18 decoy receptor IL18BP prevented the development of oxaliplatin-induced mechanical hyperalgesia; however, the IL1R antagonist anakinra did not improve oxaliplatin-induced mechanical hyperalgesia."

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"A well-characterized example of a complete self-regulated inflammatory pathway is the interleukin-1 (IL-1) system comprising the agonist cytokines IL-1α and IL-1β, and their receptor IL-1R1 (IL-1 receptor type I), which is inhibited by the IL-1 receptor antagonist IL-1Ra. xref A related system involves the three IL-36 cytokines IL-36α, IL-36β and IL-36γ, which are neutralized when the IL-36Ra binds the IL-36 receptor IL-1RL2 (also known as IL-36R)."

reach
"Similar to CAPS, DIRA patients are routinely administered with the IL-1R antagonist anakinra."

reach
"DIRA is another early-onset inflammatory disease associated with multifocal osteitis, periostitis and pustulosis, caused by loss-of-function mutations in IL1RN encoding the IL-1 receptor (IL-1R) antagonist [74, 75]."

reach
"Moreover, IL-1R antagonists, such as anakinra, might be applied alone or as complementary therapy to reinvigorate ACT and ICB in GC."