IndraLab

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IL1RN inhibits IL1R1. 57 / 60
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"To exclude that this effect was secondary to ASC and NLRP-3 dependent IL-1β activation, the transfected cells were treated with the IL-1R antagonist Anakinra."
30030504
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"Because autocrine IL-1R signaling is a critical component that drives the canonical NF-kb cascade in PDAC, the combination of the IL-1R antagonist Anakinra with nab-paclitaxel, gemcitabine, and cisplatin has been opened in a pilot clinical trial for patients with resectable or potentially resectable PDAC (NCT02550327)."
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"A well-characterized example of a complete self-regulated inflammatory pathway is the interleukin-1 (IL-1) system comprising the agonist cytokines IL-1α and IL-1β, and their receptor IL-1R1 (IL-1 receptor type I), which is inhibited by the IL-1 receptor antagonist IL-1Ra. xref A related system involves the three IL-36 cytokines IL-36α, IL-36β and IL-36γ, which are neutralized when the IL-36Ra binds the IL-36 receptor IL-1RL2 (also known as IL-36R)."
32145081
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"NLRP3-mediated diseases, such as familial cold autoinflammatory syndrome, are currently managed with biologics targeting IL-1β signaling, such as the IL1R antagonist anakinra."
33656514
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"Similarly, there was no significant difference in the effect of treatment with the IL-1R antagonist Anakinra (1.5 mg/paw) between the depleted and control groups with respect to its ability to reverse mechanical or heat nociceptive sensitization (fig."
22820848
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"The IL-1R1 antagonist anakinra prevented nephropathy in diabetic mice (160)."
34307414
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"These data indicated that the IL-1R1 antagonist Anakinra inhibited IL-1β-mediated HOXC10 upregulation and HCC invasion and metastasis."
32206125
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"The IL1R antagonist anakinra prevents development of vincristine-induced mechanical allodynia and gait disturbances."
33656514
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"IL-1R antagonist Anakinra (IL-1RA, #407616) was obtained from Calbiochem; Anakirna (C H N O S ) is a recombinant biopharmaceutical and slightly modified version of the human interleukin 1 receptor antagonist protein-IL-1RA."
34496633
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"The "immunosuppressed" group included patients who received any of the following treatments for COVID-19: systemic corticosteroids (prednisone, prednisolone, dexamethasone, methylprednisolone, hydrocortisone), the IL-1R antagonist anakinra, or the IL-6R antagonist tocilizumab."
34337096
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"MCT cells were cultured in the presence of the IL1R antagonist IL-1Rn (100 muM) for 1 h and further incubated with 10 mug/ml CsA for 6 h. Mean +/- SD from three independent experiments."
23958496
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"These findings along with the promising therapeutic achievements in COVID-19 which obtained by IL-1R antagonist Anakinra [145] and Cytosorb [146] suggested that targeting the IL-6 axis may benefit severe COVID-19 patients through the improvement of NK cell functional activity."
| PMC
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"Anakinra blocks signaling of IL-1R, a receptor for both IL-1α and IL-1β (47)."
31191559
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"Treatment of CRS with the IL-1R antagonist anakinra proved to be effective in both preclinical studies ."
34083781
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"Indeed, IL-1 was shown to be a key factor for activation of TSLP secretion in both pancreatic (22) and breast cancer (21), where the use of the IL-1R antagonist anakinra reduced TSLP availability in vitro and in vivo."
33042121
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"This activation is blocked by administration of the IL-1R blocker anakinra."
35835255
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"The advantage of this approach is that some of these drugs are already available in the clinic for the treatment of auto-inflammatory or autoimmune diseases, such as the IL-1R antagonist anakinra, the IL-1α antagonist canakinumab, the IL-6 receptor antagonist tocilizumab, and the TNF-α antibody infliximab or the TNFα receptor fusion protein etanercept."
35615063
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"These cells were treated with IL-1β alone or in combination of Anakinra (an inhibitor of IL-1R1), small inference RNA (siRNA) against IL-1R1, siRNA against c-FOS or NGF neutralising antibody."
32240297
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"Herein, we present a 33-year-old man with COVID-19-related pericarditis (COVID-19-RP) who was unresponsive to colchicine and nonsteroidal anti-inflammatory drugs, but was successfully treated with the IL-1R antagonist anakinra."
| DOI
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"However, wild-type mice treated with the IL-1R antagonist anakinra are protected from C. difficile-toxin-induced intestinal injury118."
30185915
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"Shahzad et al. found db/db mice with T2DM to be protected from kidney disease by injecting the human recombinant IL-1R antagonist anakinra (18)."
31191559
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"Additionally, the IL-1R antagonist anakinra shows frequently incomplete treatment response and IL-36 may be a more promising druggable target."
31973112
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"The proinflammatory cytokine IL1β also might contribute to TAN accumulation, polarization, and survival in the TME.109 Here again, combining the anti-IL1β antibody canakinumab or the IL1R antagonist anakinra with ICIs in clinical trials might affect both IL1β-mediated cancer cell proliferation and TANs (table 1)."
34301813
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"The above data demonstrate that NLRP3-dependent IL-1β signaling mediates the symptoms of VIPN, including mechanical allodynia and gait disturbances, and that the IL1R antagonist anakinra can prevent these adverse effects."
33656514
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"Early studies of diethylnitrosamine-induced HCC in mice have shown that IL-1α released by necrotic hepatocytes acts as an inflammatory switch that supports compensatory cell proliferation and HCC development, which could be counteracted using the IL-1R antagonist anakinra ."
33469195
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"Co-injection of mice with anti-Col7 IgG and the IL-1R antagonist anakinra significantly reduced the induction of skin lesions [129]."
31732776
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"We also measured the effect of administration of the IL-1R antagonist anakinra on arterial pressure in DOCA-salt mice."
35554390
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"Pharmacological treatment using IL-1R antagonist Anakinra improved pregnancy outcomes in an experimental mouse model [123]."
32764347
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"The IL-1R antagonist, Anakinra significantly inhibited IL-1β-induced p-NF-kB in the CCR6 + T cells and CD11c mDCs with a trending inhibition in CD14 monocytes and Lin -CD161 + CD25 + cells."
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"Treatment of animals having had tibia fracture and cast immobilization with IL-1R antagonist anakinra reduces not only the CRPS-like nociceptive sensitization, but also levels of the pro-nociceptive mediators IL-6, tumor necrosis factor α and nerve growth factor in hindpaw skin (12)."
21596883
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"On the other hand, the presence of the IL-1RN allele 2 was shown to be associated with enhanced IL-1beta production and decreased production of IL-1Ra in vitro [24]."
16423338
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"IL-1R antagonist anakinra (IL-1RA, #407616) was obtained from Calbiochem; anakinra (C759H1186N208O232S10."
34496633
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"The presence of IL-1R on skin epidermal cells and the present finding of IL-1R antagonist anakinra blocking local SP-induced skin sensitization further support this notion."
21596883
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"Canakinumab inhibits the NLRP3-inflammsome product, IL-1β, while Anakinra inhibits the IL-1β receptor (IL-1R)."
| PMC
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"Importantly, the clinically used IL1R antagonist anakinra prevented development of vincristine-induced gait abnormalities and mechanical allodynia without affecting the chemotherapy efficacy of vincristine—or tumor growth—in medulloblastoma patient-derived xenograft (PDX) models."
33656514
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"In recent years, clinical studies have found that blocking IL-1 is beneficial for IHD and can also improve cardiac remodeling in patients with STEMI, among which the IL-1R antagonist anakinra has been more thoroughly studied [97]."
35876879
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"Alternatively, IL1RN genetic variants may decrease the ability of IL-1Ra to competitively inhibit proinflammatory IL-1beta production during an inflammatory immune response, with IL-1beta ultimately influencing timing of birth."
28252571
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"Treatment of CRS with the IL-1R antagonist anakinra proved to be effective in both preclinical studies 259, 260 ."
34083781
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"We hypothesize that deletion of Il1rn induces a tonic activation of IL-1R1 signaling in presynaptic axon terminals, mediating the observed increase in action potential dependent GABA release."
25479427
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"In ASFV-infected cells, IL-1R antagonist (IL-1RN), a natural IL-1 antagonist, increases significantly and inhibits the combination of IL-1 with IL-1R, which competitively inhibits the effect of IL-1."
34552586
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"The IL-1R antagonist anakinra (50 mg/kg) or saline was i.p."
32758418
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"IL-1R can be activated by IL-1alpha and IL-1beta , and can be blocked by anakinra , whereas canakinumab can be used to prevent IL-1beta binding to IL-1R ."
36253509
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"Since blockade of IL-1R by anakinra reduced leukocyte levels in both HPV-positive and HPV-negative OPSCC in vitro, it could be argued that this antagonist may be effective for both types of tumour, however, the increased numbers of leukocytes recruited to HPV-negative OPSCC suggests that the treatment would be most effective for this cancer type."
35047989
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"In both studies, the use of the IL-1R antagonist anakinra alone and in combination with tocilizumab counteracted CAR-T CRS, leading to increased overall survival more effectively than the anti-IL6 alone."
32553791
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"Notably, the gut pathology of mice transferred with Kaede-Red+CD3 CD4 T cells was significantly attenuated by treatment with the IL-1R antagonist anakinra (Figures 6L–6O)."
32758418
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"Furthermore, the expression level of IL1R1 strongly correlates with increased neutrophils in sputum and airflow limitation of asthmatic patients and LPS-induced neutrophilic airway inflammation in healthy volunteers was attenuated by the IL1R1 antagonist anakinra ."
34953791
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"IL-1α and IL-1β bind to the same receptor, i.e., type 1 IL-1 receptor (IL-1R1), to activate the downstream signaling, whereas IL-1Ra inhibits IL-1R1 in a competitive binding manner."
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"IL-1R1 is located on the membrane surface, thus, icIL-1RA would require secretion into the extracellular space for it to block IL-1R1, although IL-1R1 intranuclear localization in oral dysplastic and cancer cells has been recently described [65]."
35048046
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"These findings along with the promising therapeutic achievements in COVID-19 which obtained by IL-1R antagonist Anakinra [144] and Cytosorb [145] suggested that targeting the IL-6 axis may benefit severe COVID-19 patients through the improvement of NK cell functional activity."
| PMC
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"XREF_BIBR The C allele of IL-1RN -1129 reduces IL-1RA, which is associated with an increased IL-1beta level that in turn inhibits gastric acid secretion."
26601827
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"However, wild-type mice treated with the IL-1R antagonist anakinra are protected from C. difficile-toxin-induced intestinal injury ."
30185915
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"IL-1R knockout mice and the IL-1R antagonist anakinra were used in two separate groups to suppress activation of IL-1R."
35554390
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"Drugs of interest include Adalimumab, Infliximab and Etanercept that inhibit TNF-α, and Anakinra that inhibits IL-1 and IL-1Ra genetic therapy, that is in the preclinical stage on the animal model [77,239]."
32722615
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"The IL-1R antagonist Anakinra significantly inhibited IL-1β-induced p-NF-kB in the CCR6 + T cells and CD11c myeloid DCs (mDC) with only a trending inhibition in CD14 monocytes and Lin -CD161 + CD25 + cells."
| DOI
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"134 Anakinra is an antagonist of the IL-1R approved for the treatment of severe rheumatoid arthritis."
33986127
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"Anakinra antagonizes the effects of IL-1β by inhibiting IL-1R1, and MCC950 stimulates the blockade of these neuroinflammatory cascades by inhibiting NLRP3, which might suppress the headache."
| PMC
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"More recently, based on our initial report of efficacy in a child with FIRES (Kenney-Jung et al., 2016; Clarkson et al., 2019), the IL-1R antagonist anakinra has been increasingly used in the treatment of these patients, with mixed results (Farias-Moeller et al., 2018; Löscher and Klein, 2021a; Yamanaka et al., 2021)."
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