IndraLab
Statements
reach
"The block of JunB protein induction in the USP38-deficient T cells was restored by the proteasome inhibitor MG132, and likewise, the degradation rate of JunB is more rapid in usp38 CD4 T cells in the presence of CHX after TCR stimulation, suggesting that USP38 stabilizes JunB protein in TCR signaling."
reach
"Analogous to the quantitative change of JunB level in the condition of the transgenic mice (Li et al., 1999), our data showed that USP38 only regulated JunB protein stability and was not required for Junb mRNA induction, and thus, there was still JunB induction in USP38-deficient CD4 T cells upon TCR stimulation."