IndraLab

Statements

CYLD inhibits IKBKE. 4 / 4
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"CYLD, long known as a tumor suppressor, has also been revealed to negatively regulate the activation of TBK1/IKKi ( Zhang et al., 2008 )."
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"The effect of CYLD was not specific to RIG-I, as CYLD also deubiquitinated and inhibited the signaling activities of TBK1 and IKKepsilon."
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"Our previous studies as well as others have demonstrated that A20, TAX1BP1, ABIN1 and CYLD inhibit TBK1 and IKKi by antagonizing their Lys63 linked polyubiquitation XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"CYLD also negatively regulates the IKK related kinases, IKKepsilon and TBK1, by the same mechanisms."
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