IndraLab

Statements

EBNA1 inhibits USP7. 4 / 4
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"USP7 silencing caused a significant decrease in transcriptional activation by EBNA1 (P value 0.004) but did not significantly affect transactivation by Delta395-450."
19834552
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"If the EBNA1-USP7 association competes with binding to these cellular proteins, EBNA1 may effectively sequester USP7 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29642420
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"This anti-apoptotic activity may be mediated by the ability of EBNA-1 to sequester the deubiquitinating enzyme HAUSP/USP7 that regulates the turnover of p53 [34,35] ."
19619655
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"EBNA-1 can also disrupt the host cell 's USP7 assisted stabilization of p53/TP53, thereby preventing the host cell from entering apoptosis, setting the stage for continual viral replication."
29234321