IndraLab

Statements

EBNA1 inhibits USP7. 7 / 7
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"If the EBNA1-USP7 association competes with binding to these cellular proteins, EBNA1 may effectively sequester USP7 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Similar to HSV1's ICP0, EBNA1 binds and inhibits USF7/ HAUSP, promoting p53 degradation by the Mdm2 pathway [27] ."
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"USP7 silencing caused a significant decrease in transcriptional activation by EBNA1 (P value 0.004) but did not significantly affect transactivation by Delta395-450."
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"Hence, inhibition of USP7 by EBNA1 may exhibit selectivity and contribute twofold to p53 destabilization."
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"EBNA-1 can also disrupt the host cell 's USP7 assisted stabilization of p53/TP53, thereby preventing the host cell from entering apoptosis, setting the stage for continual viral replication."
29234321
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"Hence, inhibition of USP7 by EBNA1 may exhibit selectivity and contribute twofold to p53 destabilization."
17291557
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"EBNA-1 can also disrupt the host cell’s USP7-assisted stabilization of p53/TP53, thereby preventing the host cell from entering apoptosis, setting the stage for continual viral replication (65)."
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