IndraLab

Statements

BAP1 activates Cell Survival. 7 / 8
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"BAP1 stabilizes BRCA1 protein and restores cell survival rates of MM cells with BAP1 deletion after IR."
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"BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress."
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"Further, downregulation of BAP1 in SK-N-FI cells by using small interfering RNA (siRNA) enhanced cell survival compared to siRNA treated control cells."
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"BAP1 depletion greatly reduced cell viability, as observed previously (Fig. 7A)."
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"Our results suggested that, whereas WT BAP1 suppresses MM cell proliferation and restores cell survival after IR damage, some mutant BAP1 may also moderately retain these functions."
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"To confirm the results of the colony formation assay and determine the mechanisms by which BAP1 activity supports colon cancer cell viability, we analyzed apoptosis by Annexin-V/PI double staining."
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"While BAP1 deletion suppresses RCC cell survival in vitro, it does not impede tumor growth in immunocompetent murine models."
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