IndraLab

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USP14 increases the amount of TNF. 6 / 6
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"USP14 can activate the non-canonical NF-κB signaling pathway and promote the expression of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-18, which interact to form a positive feedback cycle, promote lipid deposition, and ultimately induce the occurrence of AS (92, 93)."
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"To further explore the regulatory mechanism of USP14, we transfected LPS-induced GMECs with USP14 shRNA and showed that silencing USP14 significantly reduced LPS-induced secretion levels of the inflammatory cytokines IL-6, TNF-α, IL-1β and IL-12 (Supplemental Figure 2)."
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"Further, USP14 inhibition reduced both basal and TNFalpha-inducible NFkappaB activity, NFkappaB-dependent gene expression and the nuclear translocation of the NFkappaB subunit RELA."
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"USP14 overexpressed HeLa cells exhibited a decrease in RIG-I-mediated IL-6 and TNF-alpha expression."
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"Furthermore, Usp14 knockdown decreased the mRNA expressions of TNF-α and IFN-γ (Fig. 10g)."
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"Likewise, TGT dose-dependently reduced the production of TNF-α and IL-6, and decreased the mRNA levels of TNF-α, IL-6, COX-2 and iNOS in CIA mice (Figures 2A,B; Supplementary Table S2)."
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