IndraLab

Statements

USP37 binds CHEK1. 5 / 5
3 | 1 1
biogrid
No evidence text available
34509474
biogrid
No evidence text available
34509474
sparser
"Given that we have previously demonstrated USP37's interaction with CHK1 its ability to enhance CHK1 activity [ xref ], both of which are closely associated with replication fork movement, and that USP37 is also known to play a crucial role in the Homologous Recombination pathway [ xref ], we conducted a DNA fiber assay to evaluate replication fork movement at the single molecule level."
37118828
biogrid
No evidence text available
34509474
reach
"We did observe deubiquitination of CHK1 in the same assay, consistent with earlier reports.Given that we have previously demonstrated USP37's interaction with CHK1 its ability to enhance CHK1 activity [23], both of which are closely associated with replication fork movement, and that USP37 is also known to play a crucial role in the Homologous Recombination pathway [55], we conducted a DNA fiber assay to evaluate replication fork movement at the single molecule level."
37118828