IndraLab

Statements

Kcnq1ot1 inhibits KCNQ1. 4 / 4
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"Kcnq1ot1 and Airn act to negatively regulate Kcnq1 and Igf2r , respectively, which contribute to controlling genomic imprinting ( Kanduri, 2016 )."
33789104
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"Recently, it was shown that Kcnq1ot1 represses the paternal allele of Kcnq1 by interacting with the histone methyltransferases G9a and PRC2 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"In order to decipher how Kcnq1ot1 mediates silencing of the Kcnq1 cluster, the authors turned their attention to chromatin."
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"Based on our previous studies, we hypothesized that paternal expression of Kcnq1ot1 represses Kcnq1 in cis, but this effect is countered when enhancer driven activity of Kcnq1 becomes established during heart development."
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