IndraLab

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Kcnq1ot1 inhibits KCNQ1. 2 / 2
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"Recently, it was shown that Kcnq1ot1 represses the paternal allele of Kcnq1 by interacting with the histone methyltransferases G9a and PRC2 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

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"Based on our previous studies, we hypothesized that paternal expression of Kcnq1ot1 represses Kcnq1 in cis, but this effect is countered when enhancer driven activity of Kcnq1 becomes established during heart development."