IndraLab

Statements

USP12 binds WDR proteins. 3 / 3
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"Biochemical and proteomic studies showed that two WDR proteins, WDR48 (also known as USP1 associated factor, UAF1) and WDR20, interact with USP46 and USP12."
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"Together, these structural studies suggest that binding of the WDR proteins to USP12 or USP46 relatively far from the active site results in the rearrangement of several structural elements, which propagates to the catalytic triad increasing enzyme catalysis."
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"Together, these structural studies suggest that binding of the WDR proteins to USP12 or USP46 relatively far from the active site results in the rearrangement of several structural elements, which propagates to the catalytic triad increasing enzyme catalysis.These recent structural and biochemical studies complement in vivo studies of the USP-46/WDR-48/WDR-20 complex in C. elegans."
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